This is a tough one. I think 50 years ago, I would of said no, but now-a-days, people is willing to get married a couple of times over without thinking.
It's all about trust. Don't marry the bastard/gold digger if you plan on doing a prenuptial agreement. That's just my opinion. I guess I'm a bit old school.
You're rich + He's rich = no prenup
You're poor + He's rich = no prenup
You're poor + He's poor = don't get married at all